Yorkshire AI Labs

LabelWise

Protein Label Site Selection
New Analysis

Find the optimal labelling sites on your protein

Upload a PDB structure, select a fluorophore, and get scored residues with 3D visualisation.

1. Upload Protein Structure

For label site scoring, upload one PDB. For FRET analysis, upload two conformations (apo + holo).

🧬

Click or drag .pdb file

🔄

Click or drag second .pdb

or try an example: Mouse BID (single) MBP open/closed (FRET)

How it works

1
Upload

Upload your PDB structure file

2
Configure

Select chains, fluorophore, and analysis mode

3
Analyse

Get per-residue scores with interactive 3D view

Scoring Parameters

Solvent Exposure — accessibility to labelling reagents
Secondary Structure — stability of the labelling site
Conservation — evolutionary importance of the residue
Cysteine Resemblance — compatibility with cysteine-reactive dyes